N-Methyl-2-pyrrolidone.

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Review of pharmaceutical applications of N-methyl-2-pyrrolidone.

N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects ...

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Catalytic Oxidative-Extractive Deep Desulfurization of Diesel Fuel by N-methyl-2-pyrrolidone-Based Protic Acidic Ionic Liquids (PAILs)

Inexpensive and low-viscosity Protic Acidic Ionic Liquids (PAILs) of N-metheyl-2-pyrrolidone formate, acetate, and propionate abbreviated as [Hnmp][HCOO], [Hnmp][CH3COO] and [Hnmp][CH3CH2COO] respectively, were prepared and characterized by FT-IR and H-NMR. Deep oxidative and extractive desulfurization of a simulated oil and a real diesel containing 1000 ppm...

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Tissue distribution and excretion of N-methyl-2-pyrrolidone in male and female rats.

OBJECTIVES N-methyl-2-pyrrolidone (NMP) belongs to solvents widely used in the petrochemical industry a well as in the production of pesticides, veterinary drugs and paint removers. NMP is easily absorbed from the respiratory tract, digestive system and through the skin. It is a compound of slight acute toxicity that also displays moderate irritating activity. The aim of this study was to asses...

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Rapid Quantification of N-Methyl-2-pyrrolidone in Polymer Matrices by Thermal Desorption-GC/MS.

Analysis of a residual solvent in polymeric materials has become an important issue due to the increased regulations and standards for its use. N-Methyl-2-pyrrolidone (NMP) is a solvent widely used in many industries and restricted as one of the chemicals under EU REACH regulations due to its potential harmful effects. In this study, thermal desorption-gas chromatography/mass spectrometry (TD-G...

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N-methyl pyrrolidone/bone morphogenetic protein-2 double delivery with in situ forming implants.

Bone morphogenetic proteins (BMPs) are growth and differentiation factors involved during development in morphogenesis, organogenesis and later mainly in regeneration processes, in particular in bone where they are responsible for osteoinduction. For more than a decade, recombinant human (rh)BMP-2 has been used in the clinic for lumbar spinal fusion at non-physiological high dosages that appear...

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ژورنال

عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan

سال: 1983

ISSN: 0037-9980,1883-6526

DOI: 10.5059/yukigoseikyokaishi.41.880